Prince Frederik of Luxembourg died earlier this month at the age of 22. He was suffering from POLG mitochondrial disease, a rare genetic disorder affecting approximately one in 5,000 people. The young prince established the POLG Foundation in 2022 to support research and increase awareness for those who suffer from the disease. Despite his short lifespan, Frederik left an inspiring legacy behind, one that his father promised to carry on in his son’s honour. He worked relentlessly to spread the word about the disease to help others. To raise awareness and funds, the young prince collaborated with designer Donna Karan to create the MITO apparel line, which he sells through his POLG foundation. He took part in clinical studies that aided in the development of cell lines for study in Switzerland, the US, and Europe. Treatments for POLG conditions can help control symptoms and enhance quality of life, but there is currently no cure for the ailment. For confidential support call the Samaritans on 08457 90 90 90, visit a local Samaritans branch or see www.samaritans.org for details.